Multimodality Imaging in Cranial Giant Cell Arteritis: First Experience with High-Resolution T1-Weighted 3D Black Blood without Contrast Enhancement Magnetic Resonance Imaging.
Jane Maestri BrittainMichael Stormly HansenJonathan Frederik CarlsenAndreas Hjelm BrandtLene TerslevMads Radmer JensenUlrich LindbergHenrik Bo Wiberg LarssonSteffen HeegaardUffe Møller DøhnOliver Niels KlefterAnne Katrine WienckeYousif SubhiSteffen HamannBryan HaddockPublished in: Diagnostics (Basel, Switzerland) (2023)
In order to support or refute the clinical suspicion of cranial giant cell arteritis (GCA), a supplemental imaging modality is often required. High-resolution black blood Magnetic Resonance Imaging (BB MRI) techniques with contrast enhancement can visualize artery wall inflammation in GCA. We compared findings on BB MRI without contrast enhancement with findings on 2-deoxy-2-[ 18 F]fluoro-D-glucose positron emission tomography/low-dose computed tomography (2-[ 18 F]FDG PET/CT) in ten patients suspected of having GCA and in five control subjects who had a 2-[ 18 F]FDG PET/CT performed as a routine control for malignant melanoma. BB MRI was consistent with 2-[ 18 F]FDG PET/CT in 10 out of 10 cases in the group with suspected GCA. In four out of five cases in the control group, the BB MRI was consistent with 2-[ 18 F]FDG PET/CT. In this small population, BB MRI without contrast enhancement shows promising performance in the diagnosis of GCA, and might be an applicable imaging modality in patients.
Keyphrases
- contrast enhanced
- computed tomography
- magnetic resonance imaging
- high resolution
- positron emission tomography
- magnetic resonance
- giant cell
- end stage renal disease
- growth factor
- low dose
- diffusion weighted imaging
- ejection fraction
- newly diagnosed
- peritoneal dialysis
- chronic kidney disease
- mass spectrometry
- type diabetes
- metabolic syndrome
- high dose
- patient reported outcomes
- pet imaging
- adipose tissue
- recombinant human
- oxidative stress
- image quality
- weight loss
- photodynamic therapy