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Sublingual immunotherapy for 4 years increased the number of Foxp3+ Treg cells, which correlated with clinical effects.

Tetsuya TeradaMasaya MatsudaMiki InabaJunpei HamaguchiNaoki TakemotoYusuke KikuokaYuko InakaHarumi SakaeKennosuke HashimotoHayato ShimoraKazuyuki KitataniRyo KawataTakeshi Nabe
Published in: Inflammation research : official journal of the European Histamine Research Society ... [et al.] (2021)
These results suggest that 4 years of SLIT is needed to achieve sustained increases in Foxp3+ Treg cells, which are closely associated with the efficacy of SLIT.
Keyphrases
  • induced apoptosis
  • cell cycle arrest
  • regulatory t cells
  • endoplasmic reticulum stress
  • cell death
  • oxidative stress
  • signaling pathway
  • dendritic cells