Sublingual immunotherapy for 4 years increased the number of Foxp3+ Treg cells, which correlated with clinical effects.

Tetsuya TeradaMasaya MatsudaMiki InabaJunpei HamaguchiNaoki TakemotoYusuke KikuokaYuko InakaHarumi SakaeKennosuke HashimotoHayato ShimoraKazuyuki KitataniRyo KawataTakeshi Nabe

Published in: Inflammation research : official journal of the European Histamine Research Society ... [et al.] (2021)

These results suggest that 4 years of SLIT is needed to achieve sustained increases in Foxp3+ Treg cells, which are closely associated with the efficacy of SLIT.

Keyphrases

induced apoptosis
cell cycle arrest
regulatory t cells
endoplasmic reticulum stress
cell death
oxidative stress
signaling pathway
dendritic cells