Sublingual immunotherapy for 4 years increased the number of Foxp3+ Treg cells, which correlated with clinical effects.
Tetsuya TeradaMasaya MatsudaMiki InabaJunpei HamaguchiNaoki TakemotoYusuke KikuokaYuko InakaHarumi SakaeKennosuke HashimotoHayato ShimoraKazuyuki KitataniRyo KawataTakeshi NabePublished in: Inflammation research : official journal of the European Histamine Research Society ... [et al.] (2021)
These results suggest that 4 years of SLIT is needed to achieve sustained increases in Foxp3+ Treg cells, which are closely associated with the efficacy of SLIT.