Preclinical and translational pharmacology of afucosylated anti-CCR8 antibody for depletion of tumour-infiltrating regulatory T cells.

Gautham GampaPhillip SpinosaJennifer GetzYu ZhongWendy HalpernEmel EsenJohn S DaviesCassie ChouMandy KwongYingyun WangTeresita L ArenzanaVittal ShivvaMahrukh HuseniRobert HsiehJill SchartnerJames T KoerberSascha RutzIraj Hosseini

Published in: British journal of pharmacology (2024)

This work demonstrates a translational research strategy for collecting and utilizing relevant nonclinical data, developing a mechanistic PK/PD model and using a comprehensive approach to inform clinical study design for RO7502175.

Keyphrases

regulatory t cells
dendritic cells
electronic health record
big data
immune response
machine learning
stem cells