Lactic acidosis induces resistance to the pan-Akt inhibitor uprosertib in colon cancer cells.
Emily M E BarnesYitao XuAdrian BenitoLili HerendiAlexandros P SiskosEric O AboagyeAnke NijhuisHector C KeunPublished in: British journal of cancer (2020)
Lactic acidosis confers resistance to uprosertib, which can be reversed by inhibiting lactate transport or oxidative metabolism.
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