Tumor Fraction Correlates With Detection of Actionable Variants Across > 23,000 Circulating Tumor DNA Samples.
Hatim HusainDean C PavlickBernard J FendlerRussell W MadisonBrennan DeckerOle V GjoerupChristine A ParachoniakMargaret E McLaughlin-DrubinRachel L ErlichAlexa B SchrockGarrett M FramptonMeghna Das ThakurGeoffrey R OxnardHanna TukachinskyPublished in: JCO precision oncology (2022)
Elevated ctDNA shed is associated with both high sensitivity and negative predictive value for detection of actionable GAs. The presence of elevated TF suggests adequate tumor profiling and may reduce the value of subsequent reflex to confirmatory tissue testing in patients with negative LBx results.