αvβ3-Isoform specific erbium complexes highly specific for bladder cancer imaging and photodynamic therapy.

Yan ZhouChi-Fai ChanDaniel W J KwongGa-Lai LawSteven CobbWai-Kwok WongKa-Leung Wong

Published in: Chemical communications (Cambridge, England) (2017)

We have synthesized a bifunctional erbium-porphyrin tumor imaging and PDT agent (Er-R3) that is capable of killing bladder cancer cells via its selective binding to the integrin αvβ3 isoform overexpressed on the cell membrane.

Keyphrases

photodynamic therapy
fluorescence imaging
high resolution
spinal cord injury
metal organic framework
urinary tract
energy transfer
muscle invasive bladder cancer