Quality of methods and reporting in association studies of chronic periodontitis and IL1A -889 and IL1B +3953/4 SNPs: A systematic review.

Filippo Citterio Federica RomanoFrancesco FerrarottiGiacomo GualiniMario Aimetti

Published in: Journal of periodontal research (2019)

The association between IL1A -889 and IL1B +3954 polymorphisms and chronic periodontitis is questionable due to methodological inconsistency. Evidence arising from meta-analysis is unreliable due to high risk of bias and moderate quality in terms of reporting.

Keyphrases

systematic review
adverse drug
emergency department
gene expression
genome wide
meta analyses
genome wide association