Quantitative susceptibility mapping of the normal-appearing white matter as a potential new marker of disability progression in multiple sclerosis.

Anna Margherita PietroboniAnnalisa ColombiValeria E ContarinoFrancesco Maria Lo RussoGiorgio ConteAurelia MorabitoSilvia SiggillinoTiziana CarandiniChiara FenoglioAndrea ArighiMilena A De RizMarina ArcaroLuca SacchiGiorgio G FumagalliAnna Maria BianchiFabio TriulziElio ScarpiniDaniela Galimberti

Published in: European radiology (2022)

• NAWM-QSM is higher in PPMS patients than in RRMS. • NAWM-QSM seems to be a predictor of EDSS worsening over time. • Patients with higher NAWM-QSM show increased sNfL concentration and lower CSF Aβ levels.

Keyphrases

multiple sclerosis
white matter
high resolution
newly diagnosed
ejection fraction
prognostic factors
patient reported outcomes