Oxidative Stress in Neurodegenerative Diseases.
Ewa NiedzielskaIrena SmagaMaciej GawlikAndrzej MoniczewskiPiotr StankowiczJoanna PeraMałgorzata FilipPublished in: Molecular neurobiology (2015)
The pathophysiologies of neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), Parkinson's disease (PD), and Alzheimer's disease (AD), are far from being fully explained. Oxidative stress (OS) has been proposed as one factor that plays a potential role in the pathogenesis of neurodegenerative disorders. Clinical and preclinical studies indicate that neurodegenerative diseases are characterized by higher levels of OS biomarkers and by lower levels of antioxidant defense biomarkers in the brain and peripheral tissues. In this article, we review the current knowledge regarding the involvement of OS in neurodegenerative diseases, based on clinical trials and animal studies. In addition, we analyze the effects of the drug-induced modulation of oxidative balance, and we explore pharmacotherapeutic strategies for OS reduction.
Keyphrases
- oxidative stress
- amyotrophic lateral sclerosis
- drug induced
- liver injury
- clinical trial
- dna damage
- healthcare
- ischemia reperfusion injury
- diabetic rats
- gene expression
- induced apoptosis
- case control
- stem cells
- brain injury
- phase iii
- anti inflammatory
- open label
- chemotherapy induced
- innate immune
- subarachnoid hemorrhage
- electronic health record