Meltdose Tacrolimus Population Pharmacokinetics and Limited Sampling Strategy Evaluation in Elderly Kidney Transplant Recipients.

Jasper Kamp Tom C ZwartSoufian MeziyerhPaul J M van der BoogEsther E NijghKoen van DuinAiko P J de VriesDirk Jan A R Moes

Published in: Pharmaceutics (2023)

The developed population PK model adequately described the tacrolimus PK data in a population of elderly kidney transplant recipients. In addition, the developed population PK model and LSS showed an adequate estimation of tacrolimus exposure, and may therefore be used to aid in tacrolimus dose individualization.

Keyphrases

machine learning
electronic health record
deep learning
artificial intelligence
data analysis