Ubiquitin ligases HUWE1 and NEDD4 cooperatively control signal-dependent PRC2-Ezh1α/β-mediated adaptive stress response pathway in skeletal muscle cells.

Peng LiuMuhammad ShuaibHuoming ZhangSeba NadeefValerio Orlando

Published in: Epigenetics & chromatin (2019)

Together, these results shed light on key components that regulate PRC2-Ezh1α/β pathway to direct modulation of epigenome plasticity and transcriptional output in skeletal muscle cells.

Keyphrases

skeletal muscle
induced apoptosis
cell cycle arrest
insulin resistance
gene expression
endoplasmic reticulum stress
type diabetes
transcription factor
adipose tissue