Burden of respiratory viral infection in persons with human immunodeficiency virus.
Subhashini A SellersKenton L DoverAubrey G BaileyAvery ChevesAnthony B EasonElena B PopowitchMelissa B MillerDavid A WohlDirk P DittmerWilliam A FischerPublished in: Influenza and other respiratory viruses (2020)
This study was conducted to determine the prevalence of respiratory viral infections (RVI) in persons living with HIV (PLH) admitted with a respiratory complaint using real-time reverse transcription polymerase chain reaction and primer-independent next-generation sequencing (NGS). Of 82 subjects, respiratory viruses were the most common pathogen identified in 27 (33%), followed by fungus and bacteria in 8 (10%) and 4 (5%) subjects, respectively. Among subjects with RVI, 11 (41%) required ICU admission and 16 (59%) required mechanical ventilation. The proportion of respiratory viruses identified, and the associated complicated hospital course highlights the significant role that RVIs play in the lung health of PLH.
Keyphrases
- human immunodeficiency virus
- mechanical ventilation
- intensive care unit
- healthcare
- hepatitis c virus
- respiratory tract
- public health
- acute respiratory distress syndrome
- emergency department
- antiretroviral therapy
- risk factors
- hiv infected
- sars cov
- transcription factor
- dna methylation
- social media
- genome wide
- genetic diversity
- hiv positive
- cell free
- health promotion