HCN channels in the lateral habenula regulate pain and comorbid depressive-like behaviors in mice.
Xue-Zhong CaoMeng-Ye ZhuGang XuFan LiYi YanJin-Jin ZhangJianbing WangFei ZengYang BaoXue-Xue ZhangTao LiuDa-Ying ZhangPublished in: CNS neuroscience & therapeutics (2024)
Our results indicated that the LHb neurons were hyperactive under CADS in chronic pain, and this hyperactivation possibly resulted from the enhanced function of HCN channels and up-regulation of HCN2 isoforms.