Molecular, immunological and neurophysiological evaluations for early diagnosis of neural impairment in seropositive leprosy household contacts.
Diogo Fernandes Dos SantosMatheus Rocha MendonçaDouglas Eulálio AntunesElaine Fávaro Pípi SabinoRaquel Campos PereiraLuiz Ricardo GoulartIsabela Maria Bernardes GoulartPublished in: PLoS neglected tropical diseases (2018)
ELISA anti-PGL-I is the most important test in determining the increased chance of neural impairment in asymptomatic leprosy household contacts. The combination of the two assays (ELISA anti-PGL-I and peripheral blood qPCR) and the presence of BCG scar may identify individuals with higher chances of developing leprosy neuropathy, corroborating with the early diagnosis and treatment.