Inflammatory Bowel Disease Risk Variants Are Associated with an Increased Risk of Skin Cancer.

Kelly C CushingXiaomeng DuYanhua ChenL C StetsonAnnapurna KuppaVincent L ChenJ Michelle KahlenbergJohann E GudjonssonBrett VanderwerffPeter D R HigginsElizabeth K Speliotes

Published in: Inflammatory bowel diseases (2022)

The results of this study highlight shared genetic susceptibility across IBD and skin cancer, with increased risk of NMSC in those who carry risk variants in IRF4, PTPN22, CPEB4, and BACH2 and increased risk of MSC in those who carry a risk variant in IL2RA.

Keyphrases

skin cancer
copy number
gene expression
genome wide
immune response
ulcerative colitis
disease activity