Mice with epidermal filaggrin deficiency show increased immune reactivity to nickel.
Trine H PetersenMia H JeeAnne-Sofie Ø GadsbøllJonas D SchmidtJens J SlothGregory F SonnenbergCarsten GeislerJacob P ThyssenCharlotte Menné BonefeldPublished in: Contact dermatitis (2018)
These findings suggest that the increased nickel responsiveness associated with epidermal filaggrin deficiency is mediated by a combination of increased nickel penetration and the steady-state inflammation found in the skin of filaggrin-deficient mice.