Microbiota as Predictor of Mortality in Allogeneic Hematopoietic-Cell Transplantation.
Jonathan U PeledAntonio L C GomesSean M DevlinEric R LittmannYing TaurAnthony D SungDaniela WeberDaigo HashimotoAnn E SlingerlandJohn B SlingerlandMolly MaloyAnnelie G ClurmanChristoph K Stein-ThoeringerKate A MarkeyMelissa D DocampoMarina Burgos da SilvaNiloufer KhanAndré GessnerJulia A MessinaKristi RomeroMeagan V LewAmy BushLauren BohannonDaniel G BreretonEmily FontanaLuigi A AmorettiRoberta J WrightGabriel K ArmijoYusuke ShonoMíriam Sanchez-EscamillaNerea Castillo FloresAna Alarcon TomasRichard J LinLucrecia Yáñez San SegundoGunjan L ShahChristina ChoMichael ScordoIoannis PolitikosKasumi HayasakaYuta HasegawaBoglarka GyurkoczaDoris M PonceJuliet N BarkerMiguel-Angel PeralesSergio A GiraltRobert R JenqTakanori TeshimaNelson J ChaoErnst HollerJoao B XavierEric G PamerMarcel R M van den BrinkPublished in: The New England journal of medicine (2020)
Patterns of microbiota disruption during allogeneic hematopoietic-cell transplantation were similar across transplantation centers and geographic locations; patterns were characterized by loss of diversity and domination by single taxa. Higher diversity of intestinal microbiota at the time of neutrophil engraftment was associated with lower mortality. (Funded by the National Cancer Institute and others.).