Association of Early MRI Characteristics With Subsequent Epilepsy and Neurodevelopmental Outcomes in Children With Tuberous Sclerosis Complex.
Hanna M HulshofHugo J KuijfKatarzyna KotulskaPaolo CuratoloBernhard WeschkeKate RineyPavel KrsekMartha FeuchtRima NabboutLieven LagaeAnna C JansenWillem M OtteMaarten H LequinKamil SijkoArianna BenvenutoChristoph HertzbergBarbora BenovaTheresa SchollJessie De RidderEleonora M A AronicaDavid J KwiatkowskiSergiusz JozwiakElżbieta JurkiewiczKees P J BraunFloor E Jansennull nullPublished in: Neurology (2022)
This study provides Class I evidence that in infants with TSC, there is a significant association between characteristic TSC lesions on early brain MRI and the development of clinical seizures and neurodevelopmental outcomes in the first 2 years of life.