Losartan Reduces Remodeling and Apoptosis in an Adriamycin-Induced Cardiomyopathy Rat Model.

Hyeon A Kim Kwan Chang Kim Hyeryon Lee Young Mi Hong

Published in: Journal of chest surgery (2023)

In an ADR-induced cardiomyopathy rat model, co-administration of ADR with losartan presented cardioprotective effects by attenuating LV hypertrophy, pro-inflammatory factors, and apoptosis in LV tissue.

Keyphrases

oxidative stress
diabetic rats
high glucose
endoplasmic reticulum stress
heart failure
cell cycle arrest
cell death
angiotensin ii
emergency department
signaling pathway
atrial fibrillation