Endothelial-to-mesenchymal transition: a precursor to pulmonary arterial remodelling in patients with idiopathic pulmonary fibrosis.
Archana Vijay GaikwadWenying LuSurajit DeyPrem BhattaraiGreg HaugJosie LarbyCollin ChiaJade JaffarGlen WestallGurpreet Kaur SingheraTillie-Louise HackettMathew Suji EapenSukhwinder Singh SohalPublished in: ERJ open research (2023)
This is the first study to demonstrate active EndMT in size-based classified pulmonary arteries from IPF patients and potential role in driving remodelling changes. The mesenchymal markers had a negative impact on the diffusing capacity of the lungs for carbon monoxide. This work also informs early origins of pulmonary hypertension in patients with IPF.
Keyphrases
- idiopathic pulmonary fibrosis
- pulmonary hypertension
- end stage renal disease
- interstitial lung disease
- stem cells
- bone marrow
- pulmonary artery
- chronic kidney disease
- newly diagnosed
- ejection fraction
- endothelial cells
- pulmonary arterial hypertension
- prognostic factors
- rheumatoid arthritis
- coronary artery
- blood flow