Heparin reversal with protamine sulfate after Percutaneous Hepatic Perfusion (PHP): is less more?
Nadia FacchettiJan B HinrichsLena S BeckerMartin A SchneiderRoland BrüningJan RademacherJochen LenzKirsten KudrassArndt VogelFrank K WackerCornelia Lieselotte Angelika DewaldPublished in: Cancer imaging : the official publication of the International Cancer Imaging Society (2023)
Our retrospective study implies that there might be a link between the practice of protamine sulfate administration to reverse the full hemodilutive effect of UFH after PHP and the post-interventional risk of thromboembolic events as well as clinically significant thrombopenia. Our data suggest that the standard use of protamine sulfate after PHP in low-risk patients without clinical signs of active bleeding should be critically re-evaluated.