Clinical implications of Wnt pathway genetic alterations in men with advanced prostate cancer.
Amanda BroderickElizabeth PanJinju LiAlec ChuClara HwangPedro C BarataFrank Cameron CackowskiMatthew Kyle LabriolaAlyssa GhoseMehmet Asim BilenDeepak KilariBicky ThapaMichael PieroLaura S GrahamAbhishek TripathiRohan GarjeVadim S KoshkinErik HernandezTanya Barauskas DorffMichael Thomas SchweizerAjjai Shivaram AlvaRana R McKayAndrew J ArmstrongPublished in: Prostate cancer and prostatic diseases (2024)
Wnt-altered patients with prostate cancer have a higher prevalence of visceral metastases and are enriched in RB1, AR, SPOP, FOXA1, and PIK3CA alterations. Despite these associations, Wnt alterations were not associated with worse survival or treatment outcomes in men with advanced prostate cancer.