Targeting upregulated RNA binding protein RCAN1.1: a promising strategy for neuroprotection in acute ischemic stroke.
Yan YunXiaxin YangShichuan TanPin WangYanbin JiXiulian SunPublished in: CNS neuroscience & therapeutics (2022)
RCAN1.1 is a novel target gene of HIF1α and the functional HRE in the RCAN1.1 promoter region is -325 to -322 bp. The marked upregulation of RCAN1.1 in AIS promoted neuronal apoptosis, an effect that could be reversed by its RNA aptamer R1SR13 in vivo and in vitro. Thus, R1SR13 represents a promising strategy for neuroprotection in AIS and our study lays a theoretical foundation for it to become a clinically targeted drug.
Keyphrases
- drug induced
- cerebral ischemia
- binding protein
- cancer therapy
- brain injury
- oxidative stress
- dna methylation
- gold nanoparticles
- endoplasmic reticulum stress
- gene expression
- cell proliferation
- genome wide
- transcription factor
- cell death
- endothelial cells
- nucleic acid
- signaling pathway
- copy number
- subarachnoid hemorrhage
- emergency department
- drug delivery
- long non coding rna
- genome wide identification
- label free
- pi k akt