Safety of the Methotrexate-leflunomide Combination in Rheumatoid Arthritis: Results of a Multicentric, Registry-based, Cohort Study (BiobadaBrasil).
Markus BredemeierRoberto RanzaAdriana Maria KakehasiAline RanzolinInês G da SilveiraAna Cristina de Medeiros RibeiroDavid C TittonAndré L S HayataHellen M S CarvalhoBárbara S KahlowVander FernandesPaulo LouzadaManoel B BértoloÂngela L B P DuarteJosé C MacieiraJosé R S MirandaGeraldo R C PinheiroReginaldo B TeodoroMarcelo M PinheiroValéria ValimIvânio A PereiraMaria F L C SaumaGláucio R W de CastroLaurindo F da RochaSâmia A S StudartMorgana O GazzetaLeticia G da SilveiraCristiano M LupoIeda M M LaurindoPublished in: The Journal of rheumatology (2021)
In our study, MTX + LEF presented a relatively good overall safety profile in comparison to MTX + SSZ and schemes involving advanced therapies in RA.