Validated determination method of tramadol and its desmethylates in human plasma using an isocratic LC-MS/MS and its clinical application to patients with cancer pain or non-cancer pain.
Hironari TanakaTakafumi NaitoYasuaki MinoJunichi KawakamiPublished in: Journal of pharmaceutical health care and sciences (2016)
The present method with acceptable analytical performance can be helpful for evaluating the pharmacokinetics of oral tramadol, including the determination of its desmethylates, for patients with cancer pain or non-cancer pain in clinical settings.