Insulin receptor expression to predict resistance to axitinib and elucidation of the underlying molecular mechanism in metastatic renal cell carcinoma.
Masayuki TakahashiKei DaizumotoTomoya FukawaYayoi FukuharaYoshimi BandoMinoru KowadaTsogt-Ochir DondooYutaro SasakiRyotaro TomidaYoshiteru UenoMegumi TsudaYoshito KusuharaKunihisa YamaguchiYasuyo YamamotoHisanori UeharaHiroomi KanayamaPublished in: British journal of cancer (2023)
Decreased INSR in RCC could be a biomarker to predict axitinib resistance. Regarding the resistant mechanism, vascular endothelial cells with decreased INSR in RCC may secrete interferon-β and induce PD-L1.