Formation of nuclear condensates by the Mediator complex subunit Med15 in mammalian cells.
Yuanyuan ShiJian ChenWei-Jie ZengMiao LiWenxue ZhaoXing-Ding ZhangJie YaoPublished in: BMC biology (2021)
We identified that the Mediator complex subunit Med15 formed nuclear condensates and characterized their features in living cells. Our work suggests that Med15 plays a role in the assembly of transcription coactivator condensates in the nucleus and identifies Med15 regions that contribute to phase separation.