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Formation of nuclear condensates by the Mediator complex subunit Med15 in mammalian cells.

Yuanyuan ShiJian ChenWei-Jie ZengMiao LiWenxue ZhaoXing-Ding ZhangJie Yao
Published in: BMC biology (2021)
We identified that the Mediator complex subunit Med15 formed nuclear condensates and characterized their features in living cells. Our work suggests that Med15 plays a role in the assembly of transcription coactivator condensates in the nucleus and identifies Med15 regions that contribute to phase separation.
Keyphrases
  • living cells
  • fluorescent probe
  • single molecule
  • genome wide
  • transcription factor
  • protein kinase
  • gene expression