Targeting c-Met on gastric cancer cells through a fully human fab antibody isolated from a large naive phage antibody library.

Bahareh ZareiZahra JavidanElnaz FatemiFatemeh Rahimi JamnaniShohreh KhatamiVahid Khalaj

Published in: Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences (2020)

Together, our study presents a single-pot antibody library, as a valuable source for finding a range of antigen-specific Fab antibodies, and also, a fully human, high affinity and specific anti c-Met Fab antibody, C16, which has the potential of developing as a therapeutic or chemotherapeutic delivery agent for killing c-Met-positive tumor cells.

Keyphrases

endothelial cells
tyrosine kinase
induced pluripotent stem cells
pseudomonas aeruginosa
cancer therapy
drug delivery
antiretroviral therapy