Reversible and Sensitive Hg2+ Detection by a Cell-Permeable Ytterbium Complex.
Guochen BaoShuai ZhaZhenyu LiuYan-Ho FungChi-Fai ChanHongguang LiPak-Ho ChuDayong JinPeter A TannerKa-Leung WongPublished in: Inorganic chemistry (2017)
A cell-permeable ytterbium complex shows reversible binding with Hg2+ in aqueous solution and in vitroby off-on visible and NIR emission. The fast response and 150 nM sensitivity of Hg2+ detection is based upon FRET and the lanthanide antenna effect. The reversible Hg2+ detection can be performed in vitro, and the binding mechanism is suggested by NMR employing the motif structure in a La complex and by DFT calculations.
Keyphrases
- aqueous solution
- fluorescent probe
- living cells
- loop mediated isothermal amplification
- single cell
- real time pcr
- label free
- cell therapy
- single molecule
- photodynamic therapy
- density functional theory
- energy transfer
- molecular dynamics
- magnetic resonance
- stem cells
- drug delivery
- molecular docking
- molecular dynamics simulations
- mass spectrometry
- binding protein
- sensitive detection