L-lactate induces specific genome wide alterations of gene expression in cultured bovine granulosa cells.
Anja BaufeldDirk KoczanJens VanselowPublished in: BMC genomics (2019)
Our data clearly show that L-lactate alters gene expression in cultured bovine GC in a broad, but obviously specific manner. Pathway analysis revealed that the mode of L-lactate action in GC initiates angiogenic processes, but also migratory events like cell movement and axonal guidance signaling, thus supporting the transformation of GC into an early luteal phenotype.
Keyphrases
- gene expression
- dna methylation
- genome wide
- single cell
- endothelial cells
- induced apoptosis
- gas chromatography
- cell cycle arrest
- spinal cord injury
- cell therapy
- electronic health record
- metabolic syndrome
- big data
- signaling pathway
- type diabetes
- oxidative stress
- cell death
- artificial intelligence
- high resolution
- pi k akt