A Novel Method to Measure Venular Perivascular Spaces in Patients with MS on 7T MRI.

Ilena C George Annie E Arrighi-Allisan Bradley N Delman Priti Balchandani S Horng Rebecca Emily Feldman

Published in: AJNR. American journal of neuroradiology (2021)

In MS, inflammatory cells accumulate within the perivascular spaces of acute and chronic lesions. Reliance on perivascular spaces as biomarkers for MS remains uncertain because various studies have reported inconsistencies in perivascular space anatomy. Distinguishing between venular and arteriolar perivascular spaces is pathophysiologically relevant in MS. In this pilot study, we leverage susceptibility-weighted imaging at 7T to better identify perivascular spaces of venular distribution on corresponding high-resolution T2 images.

Keyphrases

mass spectrometry
high resolution
multiple sclerosis
ms ms
magnetic resonance imaging
induced apoptosis
oxidative stress
machine learning
intensive care unit
cell cycle arrest
respiratory failure
convolutional neural network
photodynamic therapy