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Vof16-miR-185-5p-GAP43 network improves the outcomes following spinal cord injury via enhancing self-repair and promoting axonal growth.

Yue HuYi-Fei SunHao YuanJia LiuLi ChenDong-Hui LiuYang XuXin-Fu ZhouLi DingZe-Tao ZhangLiu-Lin XiongLu-Lu XueTing-Hua Wang
Published in: CNS neuroscience & therapeutics (2024)
Our data indicated miR-185-5p could be a detrimental factor in SCT, and vof16 may function as a ceRNA by competitively binding miR-185-5p to modulate GAP43 in the process of self-recovery after SCT. Our study revealed a novel vof16-miR-185-5p-GAP43 regulatory network in neurological self-repair after SCT and may underlie the potential treatment target for SCI.
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