Diverse impact of xeno-free conditions on biological and regenerative properties of hUC-MSCs and their extracellular vesicles.

Sylwia Bobis-WozowiczKatarzyna KmiotekKarolina KaniaElzbieta KarnasAnna Labedz-MaslowskaMalgorzata SekulaSylwia Kedracka-KrokJacek KolczDariusz BoruczkowskiZbigniew MadejaEwa K Zuba-Surma

Published in: Journal of molecular medicine (Berlin, Germany) (2016)

Type of xeno-free media influences biological properties of UC-MSCs in vitro. Certain xeno-free media promote proliferation and differentiation ability of UC-MSCs. EVs collected from xeno-free cultures of UC-MSCs are biologically active. Xeno-free UC-MSC-EVs enhance cardiac and angiogenic potential of target cells. Type of xeno-free media determines immunomodulatory effects mediated by UC-MSC-EVs.

Keyphrases

mesenchymal stem cells
stem cells
umbilical cord
induced apoptosis
heart failure
cell proliferation
cell death
oxidative stress
left ventricular
atrial fibrillation