Pro-atherogenic medical conditions are associated with widespread regional brain metabolite abnormalities in those with alcohol use disorder.
Timothy C DurazzoEric P KraybillLauren H StephensApril C MayDieter J MeyerhoffPublished in: Alcohol and alcoholism (Oxford, Oxfordshire) (2024)
Findings suggest proatherogenic conditions in those with AUD were associated with increased compromise of neuronal integrity and cell membrane turnover/synthesis. The greater metabolite abnormalities observed in Atherogenic+ may relate to increased oxidative stress-related compromise of neuronal and glial cell structure and/or impaired arterial vasoreactivity/lumen viability.
Keyphrases
- alcohol use disorder
- cerebral ischemia
- oxidative stress
- single cell
- healthcare
- cell therapy
- white matter
- dna damage
- resting state
- bone mineral density
- low density lipoprotein
- neuropathic pain
- subarachnoid hemorrhage
- ischemia reperfusion injury
- ultrasound guided
- blood brain barrier
- spinal cord
- mesenchymal stem cells
- postmenopausal women