Alignment of microbial fitness with engineered product formation: obligatory coupling between acetate production and photoautotrophic growth.
Wei DuJoeri A JongbloetsCoco van BoxtelHugo Pineda HernándezDavid LipsBrett G OliverKlaas J HellingwerfFilipe Branco Dos SantosPublished in: Biotechnology for biofuels (2018)
This work demonstrates a novel approach to stabilize the production of target compounds in cyanobacteria that culminated in the first report of a photoautotrophic growth-coupled cell factory. The method developed is generic and can easily be extended to any other modeled microbial production system.