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Alignment of microbial fitness with engineered product formation: obligatory coupling between acetate production and photoautotrophic growth.

Wei DuJoeri A JongbloetsCoco van BoxtelHugo Pineda HernándezDavid LipsBrett G OliverKlaas J HellingwerfFilipe Branco Dos Santos
Published in: Biotechnology for biofuels (2018)
This work demonstrates a novel approach to stabilize the production of target compounds in cyanobacteria that culminated in the first report of a photoautotrophic growth-coupled cell factory. The method developed is generic and can easily be extended to any other modeled microbial production system.
Keyphrases
  • microbial community
  • single cell
  • physical activity
  • body composition
  • stem cells
  • cell therapy
  • bone marrow