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Mucins and Asthma: Are We Headed to the Revolutionary Road?

Pierachille SantusDejan RadovanovicDavide Alberto Chiumello
Published in: Journal of clinical medicine (2019)
Mucus represents the first line of defense of our respiratory tract and mucociliary clearance is essential for maintaining the homeostasis of airway epithelium. The latter mechanisms are altered in asthma and mucus plugging of proximal and distal airways is the main cause of death in cases of fatal asthma. Starting from the influential review performed by Luke R. Bonser and David J. Erle in 2017, we discuss the latest evidence in terms of mucins regulation and potential treatment of mucus hypersecretion and tissue remodeling in severe asthma.
Keyphrases
  • chronic obstructive pulmonary disease
  • respiratory tract
  • lung function
  • allergic rhinitis
  • cystic fibrosis
  • minimally invasive
  • air pollution
  • risk assessment