Guilu-Erxian-Glue alleviates Tripterygium wilfordii polyglycoside-induced oligoasthenospermia in rats by resisting ferroptosis via the Keap1/Nrf2/GPX4 signaling pathway.

Jin DingBaowei LuLumei LiuZixuan ZhongNeng WangBonan LiWen ShengQinghu He

Published in: Pharmaceutical biology (2023)

Ferroptosis resistance from GLEXG might be driven by activation of the Keap1/Nrf2/GPX4 pathway. Targeting ferroptosis is a novel approach for OAS therapy.

Keyphrases

cell death
oxidative stress
signaling pathway
diabetic rats
protein protein
high glucose
pi k akt
cancer therapy
mouse model
induced apoptosis
drug induced
small molecule
endothelial cells
drug delivery
cell proliferation