Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients.
Anna C AschenbrennerMaria MouktaroudiBenjamin KrämerMarie OestreichNikolaos AntonakosMelanie Nuesch-GermanoKonstantina GkizeliLorenzo BonaguroNico ReuschKevin BaßlerMaria SaridakiRainer KnollTal PechtTheodore S KapellosSarandia DoulouCharlotte KrögerMiriam HerbertLisa HolstenArik HorneIoanna D GemündNikoletta RovinaShobhit AgrawalKilian DahmMartina van UelftAnna DrewsLena LenkeitNiklas BruseJelle GerretsenJannik GierlichMatthias BeckerKristian HändlerMichael KrautHeidi TheisSimachew MengisteElena De DomenicoJonas Schulte-SchreppingLea SeepJan RaabeChristoph HoffmeisterMichael ToVinhVerena KeitelGereon RiekeValentina TaleviDirk SkowaschN Ahmad AzizPeter PickkersFrank L van de VeerdonkMihai G NeteaJoachim L SchultzeMatthijs KoxMonique M B BretelerJacob NattermannAntonia KoutsoukouEvangelos J Giamarellos-BourboulisThomas Ulasnull nullPublished in: Genome medicine (2021)
Our study provides novel insights in the distinct molecular subgroups or phenotypes that are not simply explained by clinical parameters. We show that whole blood transcriptomes are extremely informative for COVID-19 since they capture granulocytes which are major drivers of disease severity.