Efficient characterization of multiple binding sites of small molecule imaging ligands on amyloid-beta, tau and alpha-synuclein.

Jens SobekJunhao LiBenjamin F CombesJuan A GerezMartin T HenrichFanni F GeiblPeter R NilssonKuangyu ShiAxel RomingerWolfgang H OertelRoger M NitschAgneta NordbergHans ÅgrenRuiqing Ni

Published in: European journal of nuclear medicine and molecular imaging (2024)

, K18/full-length 2N4R-tau and αSyn fibrils suggested the existence of multiple binding sites. This approach may provide efficient characterization of compounds for neurodegenerative disease-relevant proteinopathies.

Keyphrases

small molecule
cerebrospinal fluid
high resolution
protein protein
fluorescence imaging