Targeting the eCIRP/TREM-1 interaction with a small molecule inhibitor improves cardiac dysfunction in neonatal sepsis.

Naomi-Liza DenningMonowar AzizLi DiaoJose M PrincePing Wang

Published in: Molecular medicine (Cambridge, Mass.) (2020)

Inhibition of eCIRP/TREM-1 interaction with M3 is cardioprotective, decreases inflammation, and improves survival in neonatal sepsis. Trial registration Retrospectively registered.

Keyphrases

small molecule
septic shock
oxidative stress
acute kidney injury
intensive care unit
clinical trial
study protocol
left ventricular
cancer therapy
phase ii