Water-filtered infrared A radiation hyperthermia combined with immunotherapy for advanced gastrointestinal tumours.

Pengyuan LiuJing WuLiting ChenZhenhai WuYufei WuGanlu ZhangBingqi YuBeibei ZhangNan WeiJinan ShiChuanfeng ZhangLan LeiShuhuan YuJianjun LaiZhen GuoYuli ZhengZhao JingHao JiangTingxiang WangJueyi ZhouYajun WuChuan SunJie ShenJian ZhangZhibing Wu

Published in: Cancer medicine (2024)

This study pioneered the use of WIRA whole-body infrared hyperthermia combined with ICI therapy to treat GIT and verified the feasibility and safety of HIT. The final results showed a DCR of 55.6%, with a median PFS of 53.5 days, median OS of 134 days, and an irAE incidence of 22.2%. Therefore, we believe that HIT can exert multiple synergistic sensitisation effects, thereby providing clinical benefits to patients with advanced GITs, increasing overall safety, and improving patients' QOL.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
prognostic factors
risk factors
stem cells
cancer therapy
drug delivery
radiation therapy
bone marrow