Hyperlipidemia in children and adolescents with acute lymphoblastic leukemia: A systematic review and meta-analysis.

Renate Dagsdottir LaumannLouise Lindkvist PedersenLiv Andrés-JensenChristian MølgaardKjeld Schmiegelow Thomas Leth FrandsenBodil Als-Nielsen

Published in: Pediatric blood & cancer (2023)

The overall evidence of this systematic review is limited by the small number of studies and risk of bias. Our review suggests that hypertriglyceridemia increases the risk for osteonecrosis. However, larger studies are needed to explore the clinical implications of hyperlipidemia and randomized trials investigating hyperlipidemia management and its impact on severe toxicities.

Keyphrases

acute lymphoblastic leukemia
systematic review
high fat diet
case control
meta analyses
high fat diet induced
allogeneic hematopoietic stem cell transplantation
early onset
adipose tissue
metabolic syndrome
acute myeloid leukemia