A glycan cluster on the SARS-CoV-2 spike ectodomain is recognized by Fab-dimerized glycan-reactive antibodies.

Priyamvada AcharyaWilton WilliamsRory HendersonKatarzyna JanowskaKartik ManneRobert ParksMargaret DeytonJordan SprenzVictoria StallsMegan KoppKatayoun MansouriRobert J EdwardsR Ryan MeyerhoffThomas OguinGregory SempowskiKevin SaundersBarton F Haynes

Published in: bioRxiv : the preprint server for biology (2020)

Fab-dimerized, glycan-reactive (FDG) HIV-1 bnAbs cross-react with SARS-CoV-2 spike.3.1 Å resolution cryo-EM structure reveals quaternary S2 epitope for HIV-1 bnAb 2G12.2G12 targets glycans, at positions 709, 717 and 801, in the SARS-CoV-2 spike.Our studies suggest a common epitope for FDG antibodies centered around glycan 709.

Keyphrases

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cell surface
antiretroviral therapy
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respiratory syndrome coronavirus
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human immunodeficiency virus
hepatitis c virus
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pet ct
positron emission tomography
pet imaging
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monoclonal antibody
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