Impaired kidney function biomarkers and risk of severe COVID-19: Analysis of population-based cohort data.

Yifei LinBaoshan MaYingxi YangYuxiang ChenJin HuangWeimin LiXueqing YuLiming Liang

Published in: Molecular genetics & genomic medicine (2022)

Findings from this study might point to new directions for clinicians and policymakers in optimizing risk-stratification among patients based on polygenic risk estimation and tipping points of kidney function markers. Our results call for further investigation to develop a better strategy to prevent severe COVID-19 outcomes among patients with genetic predisposition to impaired kidney function. These findings could provide a new tool for clinicians and policymakers in the future especially if we need to live with COVID-19 for a long time.

Keyphrases

coronavirus disease
sars cov
palliative care
early onset
respiratory syndrome coronavirus
gene expression
metabolic syndrome
dna methylation
genome wide
electronic health record
adipose tissue
copy number
deep learning