Phlorizin attenuates postoperative gastric ileus in rats.

Tsukasa NozuSaori MiyagishiMasatomo IshiohKaoru TakakusakiToshikatsu Okumura

Published in: Neurogastroenterology and motility (2023)

AS-induced gastric ileus is mediated via TLR4 and IL-1 signaling, which is simulated by LPS. Phlorizin improves the gastric ileus via activation of ghrelin signaling, possibly by inhibition of SGLT2. Phlorizin may be useful for the treatment of POI.

Keyphrases

inflammatory response
toll like receptor
immune response
patients undergoing
diabetic rats
high glucose
anti inflammatory
drug induced
combination therapy
oxidative stress
endothelial cells
replacement therapy