Supplementation with carnosine, a food-derived bioactive dipeptide, alleviates dexamethasone-induced oxidative stress and bone impairment via the NRF2 signaling pathway.
Xi-You LiXiao-Yuan GuXiao-Min LiJian-Gang YanXin-Liang MaoQin YuYu-Lan DuHiroshi KuriharaChang-Yu YanWei-Xi LiPublished in: Journal of the science of food and agriculture (2024)
Overall, this study underscores the potential therapeutic efficacy of carnosine in mitigating oxidative stress and bone damage induced by dexamethasone exposure, shedding light on its underlying mechanism of action by activating the NRF2 signaling pathway. © 2024 Society of Chemical Industry.
Keyphrases
- oxidative stress
- signaling pathway
- induced apoptosis
- pi k akt
- bone mineral density
- low dose
- epithelial mesenchymal transition
- high dose
- diabetic rats
- ischemia reperfusion injury
- dna damage
- soft tissue
- hydrogen peroxide
- bone loss
- bone regeneration
- mouse model
- postmenopausal women
- body composition
- cell proliferation
- climate change