From mutation to management: Advancing Langerhans cell histiocytosis treatment through combination therapies.
Akiva DiamondPublished in: British journal of haematology (2024)
The treatment landscape for relapsed Langerhans cell histiocytosis (LCH) is fraught with uncertainty due to a scarcity of data. Karri et al.'s study provides promising evidence that combining MAPK pathway inhibitors with chemotherapy could improve outcomes, even for patients with multiple relapses. Although larger studies are needed, this approach suggests a shift towards more aggressive, potentially curative strategies in the management of LCH. Commentary on: Karri et al. Clinical, radiological and molecular responses to combination chemotherapy with MAPK pathway inhibition in relapsed and refractory Langerhans cell histiocytosis. Br J Haematol 2024;204:1882-1887.
Keyphrases
- single cell
- cell therapy
- acute lymphoblastic leukemia
- signaling pathway
- acute myeloid leukemia
- oxidative stress
- diffuse large b cell lymphoma
- stem cells
- multiple myeloma
- type diabetes
- locally advanced
- squamous cell carcinoma
- electronic health record
- mesenchymal stem cells
- radiation therapy
- adipose tissue
- rectal cancer
- machine learning
- skeletal muscle
- insulin resistance
- big data