The Dysregulation of SOX Family Correlates with DNA Methylation and Immune Microenvironment Characteristics to Predict Prognosis in Hepatocellular Carcinoma.

Sha QinGaoming LiuHaoer JinXue ChenJiang HeJuxiong XiaoYan QinYitao Mao Luqing Zhao

Published in: Disease markers (2022)

SOX family genes could predict the prognosis of HCC. In addition, the regulation of angiogenesis-related signaling pathways may participate in the development of HCC. DNA methylation level and immune microenvironment characteristics (especially CD4+ T cell and macrophage immune cell infiltration) could be a novel insight for predicting prognosis in HCC.

Keyphrases

dna methylation
stem cells
genome wide
transcription factor
gene expression
signaling pathway
endothelial cells
vascular endothelial growth factor
oxidative stress
endoplasmic reticulum stress
induced apoptosis