Modulation of left ventricular diastolic filling during exercise in persons with cervical motor incomplete spinal cord injury.
Monira I AldhahiAndrew A GuccioneLisa M K ChinJoshua WoolstenhulmeRandall E KeyserPublished in: European journal of applied physiology (2019)
EDV (at peak exercise:131.4 ± 7.3 vs 188.78 ± 9.4, p < 0.001; at isomax: 131.4 ± 7.3 vs 169 ± 23, p = 0.0009) and EDFR (at peak exercise 73 ± 14% vs 119 ± 11%, p = 0.006; at isomax 94 ± 10; p = 0.009) were significantly reduced in icSCI compared to CON, respectively. Significant differences in LVET (icSCI: 273 ± 48 vs CON: 305 ± 68; p = 0.1) and dZ/dT2 (icSCI: 0.64 ± 0.11 vs CON: 0.85 ± 0.31; p = 0.1) were not observed at isomax, despite a significant decrease in SV in the subjects with icSCI (77.1 ± 6.05 mL vs 105.8 ± 9.2 mL, p < 0.00) CONCLUSION: Left ventricular filling was impaired in the subjects with icSCI as evidenced at both peak exercise and isomax. It is likely that restrictions on the skeletal muscle pump mechanized the impairment but increased left ventricular wall stiffness could not be excluded as a mediator.
Keyphrases
- left ventricular
- high intensity
- spinal cord injury
- skeletal muscle
- physical activity
- hypertrophic cardiomyopathy
- heart failure
- acute myocardial infarction
- resistance training
- cardiac resynchronization therapy
- aortic stenosis
- left atrial
- insulin resistance
- blood pressure
- adipose tissue
- metabolic syndrome
- ejection fraction
- acute coronary syndrome
- atrial fibrillation