Imaging-Guided Chemo-Photothermal Polydopamine Carbon Dots for EpCAM-Targeted Delivery toward Liver Tumor.
Zeyu LiJiatong NiLiping LiuLiyuan GuZhiguang WuTianlong LiKrasnyuk Ivan IvanovichWancheng ZhaoTiedong SunTing WangPublished in: ACS applied materials & interfaces (2021)
We demonstrate a versatile nanoparticle with imaging-guided chemo-photothermal synergistic therapy and EpCAM-targeted delivery of liver tumor cells. EpCAM antibody (anti-EpCAM) and Pt(IV) were grafted onto the polydopamine carbon dots (PDA-CDs) by the amidation reaction. The EpCAM antibody of particles enables the targeted interaction with liver progenitor cells due to their overexpressed EpCAM protein. The tetravalent platinum prodrug [Pt(IV)] induces apoptosis with minimum toxic side effects through the interaction between cisplatin and tumor cell DNA. The nanoparticles displayed stable photothermal property and considerable anti-tumor therapeutic effect in vivo. Coupling with cellular imaging due to their fluorescence property, anti-EpCAM@PDA-CDs@Pt(IV) offers a convenient and effective platform for imaging-guided chemo-photothermal synergistic therapy toward liver cancers in the near future.
Keyphrases
- cancer therapy
- circulating tumor cells
- cell adhesion
- photodynamic therapy
- drug delivery
- high resolution
- circulating tumor
- drug release
- fluorescence imaging
- quantum dots
- single molecule
- locally advanced
- mesenchymal stem cells
- stem cells
- small molecule
- high throughput
- radiation therapy
- mass spectrometry
- magnetic nanoparticles
- visible light
- amino acid